Maturity-onset diabetes of the young type 10 caused by an Ala2Thr mutation of INS: A case report

Table 3 Clinical and biochemical parameters of all Ala2Thr mutation carriers

	Our study		Zhang et al[7]				Yan et al[6]
No.	1	2	1	2	3	4	1	2	3	4	5	6
Age (yr)	53	48	25	46	42	69	/	47	66	58	34	62
Sex	Female	Female	Male	Female	Male	Male	Male	Male	Male	Female	Male	Male
Onset age of diabetes (yr)	27	Around 40	22	39	33	50	31	47	66	54	34	57
BMI (kg/m2)	20.24	23.5	21.7	23.9	21	24.2	/	24.54	24.21	28.94	23	23.1
HbA1c (%)	9.1	/	7.6	6.8	7.7	9.8	/	5.6	7.6	7.7	10.9	7.2
FBG (mmol/L)	6.8	/	9.3	7.8	8.3	9.6	16	5.65	8.98	9.44	5.53	8.34
PBG (mmol/L)	21.8	/	11.9	12.7	15.2	17.8	/	5.02	18.82	19.99	17.69	16.85
FINS (pmol/L)	/	/	51.54	61.30	57.11	84.28	/	48.84	26.52	277.56	56.04	85.8
PINS (pmol/L)	/	/	206.16	190.84	134.42	314.12	/	507.3	52.62	562.62	121.38	478.26
FCP (pmol/L)	135.4	/	/	/	/	/	/	/	/	/	/	/
PCP (pmol/L)	600.1	/	/	/	/	/	/	/	/	/	/	/
GADA	+	/	-	-	-	-	-	-	-	-	-	-
IA-2A	/	/	-	-	-	-	-	-	-	-	-	-
Diagnosis	DM	DM	DM	DM	DM	DM	DM	IGT	DM	DM	DM	DM
Complications	DKD, DPN, macroangiopathy	None	/	/	/	/	/	/	/	/	/	/
Therapy	OHA + Insulin	Insulin	OHA→Insulin	OHA	OHA	OHA	OHA	-	OHA	-	OHA	OHA

BMI: Body mass index; HbA1c: Hemoglobin A1c; FBG: Fasting blood glucose; PBG: 2h postprandial blood glucose; FINS: Fasting insulin; PINS: 2h postprandial insulin; FCP: Fasting C-peptide; PCP: 2h postprandial C-peptide; GADA: Glutamic acid decarboxylase antibody; IA-2A: Islet antigen 2 antibody; DM: Diabetes mellitus; DKD: Diabetic kidney disease; DPN: Diabetic peripheral neuropathy; OHA: Oral hypoglycemic agent; IGT: Impaired glucose tolerance.