Acupuncture in diabetic peripheral neuropathy-neurological outcomes of the randomized acupuncture in diabetic peripheral neuropathy trial

Table 2 Overview of the outcome parameters

Outcome	Week	Acupuncture group adj. mean (95%CI)	Control group adj. mean(95%CI)	Difference adj. mean (95%CI)	P value
NRS 11 numbness	8	4.2 (3.1; 5.2)	6.5 (5.4; 7.6)	2.3 (1.3; 3.4)	< 0.001
	16	4.6 (3.7; 5.6)	6.8 (5.8; 7.9)	2.2 (1.3; 3.1)	< 0.001
NPSI	8	17.4 (13.5; 21.4)	30.0 (26.0; 34.0)	12.6 (7.1; 18.0)	< 0.001
	16	20.9 (16.2; 25.6)	32.6 (27.8; 37.4)	11.7 (5.0; 18.4)	< 0.001
NDS	8	7.0 (6.1; 8.0)	8.1 (7.1; 9.1)	1.0 (0.2; 1.9)	0.021
	16	7.3 (5.7; 9.0)	8.2 (6.5; 9.9)	0.9 (0.1; 1.7)	0.035
NSS	8	6.3 (5.8; 6.8)	7.6 (7.1; 8.1)	1.3 (0.6; 2.0)	< 0.001
	16	6.0 (4.1; 7.9)	7.4 (5.4; 9.3)	1.4 (0.4; 2.3)	0.005
TNSc	8	7.8 (5.7; 9.8)	9.8 (7.7; 11.9)	2.0 (0.9; 3.1)	< 0.001
	16	8.3 (6.8; 9.8)	10.1 (8.5; 11.7)	1.8 (0.5; 3.1)	0.010
N. suralis CV (m/s)	8	38.2 (36.1; 40.4)	38.6 (36.4; 40.7)	0.4 (-2.7; 3.5)	0.818
	16	38.8 (33.5; 44.1)	38.8 (33.6; 44.1)	0.0 (-6.2; 6.3)	0.988
N. suralis ampl. (µV)	8	3.8 (3.3; 4.4)	4.4 (3.8; 4.9)	0.6 (-0.2; 1.3)	0.156
	16	4.2 (3.5; 5.0)	4.6 (4.0; 5.3)	0.4 (-0.6; 1.4)	0.428

NRS-11: 11 point numeric ratings scale; NPSI: Neuropathic pain symptom inventory; NDS: Neuropathy deficit score; NSS: Neuropathy symptom score; TNSc: Total clinical ceuropathy score; CV: Conduction velocity.