Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients

doi:10.4239/wjd.v14.i12.1754

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Dec 15, 2023; 14(12): 1754-1765
Published online Dec 15, 2023. doi: 10.4239/wjd.v14.i12.1754

Table 3 Biochemical parameters in diabetic coronary artery disease patients and non-diabetic coronary artery disease patients

Biochemical parameters	Group I, median (25%-75% quartile)	Group II, median (25%-75% quartile)	P value¹
Total cholesterol in mg/dL	143.50 (118.00-183.50)	132.00 (100.25-163.75)	0.006²
Triglycerides in mg/dL	150.00 (106.25-214.00)	114.00 (75.00-148.75)	0.001²
HDL-C in mg/dL	33.40 (27.33-38.98)	34.55 (28.70-41.00)	0.449²
LDL-C in mg/dL	78.00 (53.50-108.80)	73.00 (52.00-92.75)	0.278²
VLDL-C in mg/dL	29.00 (20.85-42.00)	23.00 (15.00-30.00)	0.001²
Random blood sugar in mg/dL	213.00 (131.50-275.75)	113.00 (99.00-135.00)	0.001²
HbA1c as %	8.09 (7.10-10.20)	5.70 (5.40-5.98)	0.001²
Urea in mg/dL	29.00 (23.00-39.60)	28.55 (24.85-34.00)	0.177²
Creatinine in mg/dL	0.90 (0.80-1.20)	1.00 (0.80-1.10)	0.811²
Total bilirubin in mg/dL	0.40 (0.30-0.70)	0.50 (0.40-0.69)	0.260²
Total protein in gm/dL	7.10 (6.80-7.60)	7.10 (6.73-7.48)	0.441²
Albumin in gm/dL	4.20 (4.00-4.40)	4.28 (4.00-4.50)	0.281²
ALP in U/L	108 (87.00-133.00)	95.50 (84.25-110.00)	0.054²
SGOT in U/L	26 (21.00-45.00)	30.00 (22.00-47.50)	0.240²
SGPT in U/L	28 (20.00-43.00)	29.95 (22.00-49.00)	0.187²
Sodium in mEq/L	136.00 (134.00-139.00)	139.00 (136.00-141.00)	0.001²
Potassium in mEq/L	4.60 (4.30-4.90)	4.35 (4.10-4.80)	0.002²
CML in ng/mL	264.43 (193.19- 364.34)	250.68 (195.95-333.70)	0.031²
IL-6 in pg/mL	2.75 (1.36-5.50)	2.36 (1.23-3.60)	0.011²
TNF-α in pg/mL	20.2 (13.65-25.32)	15.67 (11.137-21.785)	0.006²
Nitric oxide in nmol/mL	87.09 (59.84-124.37)	110.86 (77.00-150.00)	0.002²

¹P value < 0.05 is considered significant.

²Mann Whitney U test.

Group I: Diabetic coronary artery disease patients; Group II: Non-diabetic coronary artery disease patients. ALP: Alkaline phosphatase; CML: Nε-carboxymethyl-lysine; HbA1c: Glycosylated hemoglobin; HDL-C: High-density lipoprotein cholesterol; IL-6: Interleukin-6; LDL-C: Low-density lipoprotein cholesterol; SGOT: Glutamic-oxalacetic transaminase; SGPT: Glutamic-pyruvic transaminase; TNF-α: Tumor necrosis factor-alpha; VLDL-C: Very low-density lipoprotein cholesterol.

Citation: Shrivastav D, Singh DD, Mir R, Mehra P, Mehta V, Dabla PK. Comparative analysis of Nε-carboxymethyl-lysine and inflammatory markers in diabetic and non-diabetic coronary artery disease patients. World J Diabetes 2023; 14(12): 1754-1765
URL: https://www.wjgnet.com/1948-9358/full/v14/i12/1754.htm
DOI: https://dx.doi.org/10.4239/wjd.v14.i12.1754