Exploring the targets and molecular mechanism of glycyrrhetinic acid against diabetic nephropathy based on network pharmacology and molecular docking

Figure 7 Impact of glycyrrhetinic acid on signal proteins in the phosphatidylinositol 3-kinase/protein kinase B signaling pathway. A: Expression levels of insulin receptor and glycogen synthase kinase-3 proteins; B: Protein levels of phosphatidylinositol 3-kinase (PI3K)/p-PI3K and protein kinase B (AKT)/p-AKT. The sequence from left to right represents the control group, the model group, and the glycyrrhetinic acid group. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. GA: Glycyrrhetinic acid; CON: Control; MOD: Model; GSK3: Glycogen synthase kinase-3; INSR: Insulin receptor; AKT: Protein kinase B; PI3K: Phosphatidylinositol 3-kinase.