Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development

doi:10.4239/wjd.v14.i11.1621

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World Journal of Diabetes

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1948-9358

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World J Diabetes. Nov 15, 2023; 14(11): 1621-1631
Published online Nov 15, 2023. doi: 10.4239/wjd.v14.i11.1621

Table 1 Transcription factors and long noncoding RNAs in insulin resistance

Factors related to the development of IR	Names of lncRNAs	Targeted nuclear proteins
Lipogenic activity	H19, MALAT1, MEG3, and MIAT↑	SREBP-1c, PPARγ, and FoxO1
Gluconeogenesis	MEG3 and H19↑	CRTC2/CREB, FoxO1, HNF4A and ATF4
Inflammation and oxidative stress	MALAT1 and H19↑	EZH2 and PRC2
Cellular dysfunction	MEG3, MALAT1 and MIAT↑	N/A

lncRNA: Long noncoding RNA; IR: Insulin resistance; SREBP-1c: Sterol reg-ulatory element binding protein-1c; PPARγ: Peroxisome proliferator-activated receptor γ; FoxO1: Forkhead box protein O1; CRTC2/CREB: CREB-regulated transcription coactivator 2; HNF4A: Recombinant hepatocyte nuclear factor 4α; ATF4：Recombinant activating transcription factor 4; EZH2: Enhancer of zeste homolog 2; N/A: Not applicant.

Citation: Guo YC, Cao HD, Lian XF, Wu PX, Zhang F, Zhang H, Lu DH. Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development. World J Diabetes 2023; 14(11): 1621-1631
URL: https://www.wjgnet.com/1948-9358/full/v14/i11/1621.htm
DOI: https://dx.doi.org/10.4239/wjd.v14.i11.1621