Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development

doi:10.4239/wjd.v14.i11.1621

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 14, Issue 11

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3054)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-3) series.

Item

Count

PDF

WORD

HTML

1341

Figures (1-1)

206

Tables (1-3)

203

Sum=1859

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

149

Download

379

Sum=528

Publishing Process of This Article

Item

Count

Browse

179

Download

359

Sum=538

Nov 15, 2023 (publication date) through Jan 7, 2025

Times Cited of This Article

Times Cited (4)

Journal Information of This Article

Publication Name

World Journal of Diabetes

ISSN

1948-9358

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Diabetes. Nov 15, 2023; 14(11): 1621-1631
Published online Nov 15, 2023. doi: 10.4239/wjd.v14.i11.1621

Table 1 Transcription factors and long noncoding RNAs in insulin resistance

Factors related to the development of IR	Names of lncRNAs	Targeted nuclear proteins
Lipogenic activity	H19, MALAT1, MEG3, and MIAT↑	SREBP-1c, PPARγ, and FoxO1
Gluconeogenesis	MEG3 and H19↑	CRTC2/CREB, FoxO1, HNF4A and ATF4
Inflammation and oxidative stress	MALAT1 and H19↑	EZH2 and PRC2
Cellular dysfunction	MEG3, MALAT1 and MIAT↑	N/A

lncRNA: Long noncoding RNA; IR: Insulin resistance; SREBP-1c: Sterol reg-ulatory element binding protein-1c; PPARγ: Peroxisome proliferator-activated receptor γ; FoxO1: Forkhead box protein O1; CRTC2/CREB: CREB-regulated transcription coactivator 2; HNF4A: Recombinant hepatocyte nuclear factor 4α; ATF4：Recombinant activating transcription factor 4; EZH2: Enhancer of zeste homolog 2; N/A: Not applicant.

Citation: Guo YC, Cao HD, Lian XF, Wu PX, Zhang F, Zhang H, Lu DH. Molecular mechanisms of noncoding RNA and epigenetic regulation in obesity with consequent diabetes mellitus development. World J Diabetes 2023; 14(11): 1621-1631
URL: https://www.wjgnet.com/1948-9358/full/v14/i11/1621.htm
DOI: https://dx.doi.org/10.4239/wjd.v14.i11.1621