Copyright
©The Author(s) 2023.
World J Diabetes. Oct 15, 2023; 14(10): 1463-1477
Published online Oct 15, 2023. doi: 10.4239/wjd.v14.i10.1463
Published online Oct 15, 2023. doi: 10.4239/wjd.v14.i10.1463
Table 3 Lipid metabolism dysfunctions affecting on diabetes
| Defect | Consequence | Ref. |
| Fat buildup in insulin effector cells (liver cells, muscle cells, and adipocytes) | Insulin resistance, lipotoxicity, β-cell disruption | Muoio and Newgard [112] |
| Adipose mitochondrial dysfunction | ↑ Fatty acids levels, insulin resistance | Sparks et al[113] |
| Inactivated Foxa2 | Lipid deposits in the liver, insulin resistance | Wolfrum et al[114] |
| ↓ Malonyl Co-A in liver | ↑ Fat oxidation, ↓ circulating free fatty acids, ↑ insulin sensitivity in both muscle and liver | An et al[115] |
- Citation: Wang H, Akbari-Alavijeh S, Parhar RS, Gaugler R, Hashmi S. Partners in diabetes epidemic: A global perspective. World J Diabetes 2023; 14(10): 1463-1477
- URL: https://www.wjgnet.com/1948-9358/full/v14/i10/1463.htm
- DOI: https://dx.doi.org/10.4239/wjd.v14.i10.1463