In vivo evaluation and mechanism prediction of anti-diabetic foot ulcer based on component analysis of Ruyi Jinhuang powder

Table 4 Ruyi Jinhuang powder “Chinese medicine-ingredients-target” correspondence

CAS	Name	GenecardID	Attribution
512-61-8	(-)-α-Santalene	PTGS2, CHRM2	JH
87-44-5	Caryophyllene	PTGS2, CHRM2	BZ, JH, CZ, ZHP, TNX
495-60-3	α-Zingiberene	PTGS2, DPP4	JH
20307-83-9	β-Sesquiphellandrene	PTGS2	JH
644-30-4	α-Curcumene	PTGS2, TOP2A, DPP4	JH
1139-30-6	Caryophyllene oxide	CHRM2, DPP4	ZHP, TNX
639-99-6	Elemol	CHRM2	ZHP, JH
58334-55-7	Zingiberenol	CHRM2	JH
6989-21-5	Atractylon	SCN5A, CHRM4, HTR2A, CHRM2, OPRM1	CZ
82508-14-3	2-methyl-6-(4-methylidenecyclohex-2-en-1-yl)hept-2-en-4-one	PTGS2, CHRM2	JH, ZHP, CZ
112-39-0	Methyl palmitate	PTGS2, IL-10, TNF, IL-6	JH, ZHP, BZ, HB, THF
473-15-4	beta-Eudesmol	CHRM2	ZHP, JH, CZ
532-65-0	(6S)-2-methyl-6-(4-methylphenyl)hept-2-en-4-one	DPP4, PTGS2, CHRM2x, ampC	JH
112-62-9	Methyl oleate	RXRA	ZHP, THF
1937-62-8	trans-octadec-9-enoicacidmethylester	RXRA	ZHP, THF
112-63-0	methyl linoleate	PTGS2, RXRA	BZ, THF, ZHP, TNX
301-00-8	9,12,15-Octadecatrienoic acid, methyl ester, (Z,Z,Z)-	PTGS2, RXRA	THF
38142-57-3	2-Methyl-6-(p-tolyl)hept-2-en-4-ol	PTGS2, CHRM2, DPP4, ampC, RXRA	THF, ZHP, TNX
1957—10—3	Palmitic acid	PTGS2, IL-10, TNF, PCYT1A	DH, ZHP, THF
149-91-7	Gallic acid	PTGS2, PTPN1, TOP2A	DH, TNX, CP, GC, JH
23313-21-5	Emodin-8-Beta-D-Glucoside	TOP2A	DH
458-37-7	Curcumin	PTGS2, PTPN1	JH
22608-11-3	Demethoxycurcumin	PTGS2, PTPN1, AKR1B1, ABCB1, SCN5A	JH
520-26-3	Hesperidin	PTGS2	CP
14259-47-3	isosakuranetin-7-O-rutinoside	TOP2A	CP
10236-47-2	Naringin	TOP2A, CDKN1A, TNF, RASGRF2, RAF, PTGS2, ampC, MTTP, APOB, mvaA, PPARA	CP, GC
21967-41-9	Baicalin	PTPN1, TOP2A	DH
88191-48-4	Catechin	CHRM2	DH, CP
491-70-3	Luteolin	PTGS2, DPP4, EGFR, IL10, CDK4, TNF, IL6, NFKBIA, psdA1, IL2, TOP2A, SLC2A4, INSR, MET	CP, ZHP
551-15-5	Liquiritin	PTGS2	GC
478-43-3	Rheic acid	PTGS2, AKR1B1	DH
2086-83-1	Berberine	PTGS2, RXRA	HB
77-92-9	Citric acid	PTGS2, AKR1B1, GRIN2A, GRIA2, PTPN1	DH
320-77-4	Isocitric acid	PTGS2	DH
7200-25-1	DL-Arginine	PTGS2	THF
446-72-0	Genistein	PTGS2, EGFR, TNF, SELE, IL8	GC
482-45-1	Isoimperatorin	PTGS2	BZ
486-66-8	Daidzein	PTGS2, RXRA	GC
6831-17-0	Aristolone	CHRM2, PTGS2	BZ
532-65-0	(+) -ar-Turmerone	PTGS2, RXRA, CHRM2, ampC, DPP4	JH
327-97-9	Chlorogenic acid	PTGS2	HB
77-95-2	D-(-)-Quinic acid	PTGS2	HB
1460-73-7	Agarospirol	CHRM2	ZHP

TNF: Tumor necrosis factor; IL: Interleukin; PTGS2: Posttranscriptional silencing; TOP2A: Topoisomerase II alpha; CHRM2: Muscarinic acetylcholine receptor M2; RXRA: Retinoic X receptor alpha; DPP4: Dipeptidyl peptidase 4; SCN5A: Sodium voltage-gated channel alpha subunit 5; HTR2A: 5-hydroxytryptamine (serotonin) receptor 2A; OPRM1: Opioid Receptor Mu 1; EGFR: Epidermal Growth Factor Recepto; PTPN1: Protein tyrosine phosphatase nonreceptor type 1; THF: Trichosanthin (Tian Hua); DH: Rhubarb (Da Huang); HB: Phellodendron (Huang Bai); JH: Turmeric (Jiang Huang); BZ: Angelica dahurica (Bai Zhi); TNX: Arisaema (Tian Nan Xing); CZ: Atractylodes lancea (Cang Zhu); HP: Magnolia officinalis (Hou Po); CP: Pericarpium Citri Reticulatae (Chen Pi); GC: Glycyrrhiza uralensis (Gan Cao).