Immediate-release tofacitinib reduces insulin resistance in non-diabetic active rheumatoid arthritis patients: A single-center retrospective study

Figure 3 Homeostatic model assessment-insulin resistance and Quantitative Insulin Sensitivity Check Index levels in 26 active rheumatoid arthritis patients exposed to biologic agents before and 24 wk after tofacitinib therapy. A: Homeostatic model assessment (HOMA)-insulin resistance (IR) levels in all 26 patients at weeks 0 and 24 after tofacitinib (TOF) therapy (P = 0.016); B: HOMA-IR levels in the high-IR group with 19 patients at weeks 0 and 24 after TOF therapy (P = 0.018); C: HOMA-IR levels in the low-IR group with 7 patients at weeks 0 and 24 after TOF therapy; D: Quantitative Insulin Sensitivity Check Index (QUICKI) levels in all 26 patients at weeks 0 and 24 after TOF therapy (P = 0.016); E: QUICKI levels in the high-IR group with 19 patients at weeks 0 and 24 after TOF therapy (P = 0.008); F: QUICKI levels in the low-IR group with 7 patients at weeks 0 and 24 after TOF therapy. QUICKI: Quantitative Insulin Sensitivity Check Index; HOMA-TR: Homeostatic model assessment-insulin resistance.