Hemoglobin within normal range is negatively related to hemoglobin A1c in a nondiabetic American population aged 16 years and older

Table 3 Age- and sex-stratified analysis of correlation for hemoglobin (g/dL) and hemoglobin A1c (%)

	Unadjusted model β (95%CI)	Minimally adjusted model β (95%CI)	Fully adjusted model β (95%CI)
Stratified by age
16-29	-0.011 (-0.015, -0.008)a	-0.054 (-0.059, -0.048)a	-0.104 (-0.110, -0.097)a
30-51	-0.004 (-0.008, 0.001)	-0.037 (-0.042, -0.031)a	-0.090 (-0.097, -0.083)a
52-85	-0.021 (-0.025, -0.016)a	-0.023 (-0.028, -0.017)a	-0.084 (-0.091, -0.077)a
Stratified by sex
Men	-0.057 (-0.062, -0.052)a	-0.031 (-0.036, -0.027)a	-0.085 (-0.091, -0.080)a
Women	-0.012 (-0.017, -0.007)a	-0.033 (-0.038, -0.029)a	-0.091 (-0.096, -0.085)a

^aP < 0.0001.

Three models were employed to analyze the relation in this work, namely, unadjusted model, minimally adjusted model, and fully adjusted model. No covariates were regulated in unadjusted model. Only age was regulated in minimally adjusted model. Lastly, in fully adjusted model, all parameters were regulated, including age, gender, ethnicity, educational level, marital status, smoking behavior, body mass index, uric acid, total protein, serum creatinine, blood glucose, alanine aminotransferase, cholesterol, platelet count, and red/ white blood cell count.