Large-scale functional connectivity predicts cognitive impairment related to type 2 diabetes mellitus

Figure 1 The prediction and classification flowchart. A: Relevant information from image preprocessing to feature identification; B: Detailed steps of connectome-based predictive modeling; C: Detailed steps of support vector machine. rs-fMRI: Resting state functional magnetic resonance imaging; HOA -112: Harvard Oxford atlas; AAL-116: Automated Anatomical Labeling; Power-264: 264-region functional atlas introduced by Power et al; FCM: Functional connectivity matrix; MoCA: Montreal Cognitive Assessment; T2DM: Type 2 diabetes mellitus; T2DM-C/T2DM-NC: Patients with T2DM with the presence/absence of mild cognitive impairment; HC: Healthy controls; LOOCV: Leave-one-out cross validation; FC: Functional connectivity.