Non-coding RNAs: Role in diabetic foot and wound healing

Table 1 Micro-RNAs in diabetic foot and wound healing

Name	Expression	Animal	Target gene	Pathway	Phase	Ref.
miRNA-217	Up	Mouse	HIF-1α	VEGF	Inflammation	Lin et al[32], 2019
miRNA-23c	Up	/	SDF-1α	SDF-1α/CXCL12	Inflammation	Amin et al[33], 2020
miRNA-497	Down	Mouse	IL-1β, IL-6, TNF-α	NF-κB	Inflammation	Ban et al[34], 2020
miRNA-155	Up	Mouse	FGF7	/	Inflammation/regeneration	Moura et al[36], 2019; Gondaliya et al[51], 2022
miRNA-18a/19a	Up	/	TSP-1	/	Proliferation	Wang et al[40], 2020
miRNA-15a-3p	Up	Mouse	NOX5	ROS	Proliferation	Xiong et al[41], 2020
miRNA-152-3p	Up	Mouse	PTEN	/	Proliferation	Xu et al[45], 2020
miRNA-133b	Up	Mouse	EGFR	/	Proliferation	Zhong et al[46], 2021
miRNA-195-5p	Up	Rat	VEGFA	/	Proliferation	Liu et al[42], 2021
miRNA-205-5p	Up	Rat	VEGFA	/	Proliferation	Liu et al[42], 2021
miRNA-199a-5p	Up	Rat	VEGFA, ROCK1	/	Proliferation	Wang et al[49], 2022
miRNA-203	Up	Rat	IL-8	AKT	Regeneration	Yuan et al[52], 2019
		/	p63	/	Regeneration	Liu et al[53], 2022
miR-489-3p	Up	Rat	SIRT1	PI3K/AKT/eNOS	Regeneration	Huang et al[47], 2022
miRNA-21-3p	Down	Mouse	SPRY1	FGF	Regeneration	Wu et al[56], 2020
miRNA-146a	Down	/	AKAP12	Wnt/β-catenin	Regeneration	Peng et al[57], 2022
		/	TLR4	NF-κB	Inflammation	Zhang et al[58], 2022

HIF-1α: Hypoxia-inducible factor 1 α; VEGF: Vascular endothelial growth factor; SDF-1α: Stromal cell-derived factor-1α; IL: Interleukin; TNF: Tumor necrosis factor; FGF7: Fibroblast growth factor 7; TSP-1: Thrombospondin-1; NOX5: NADPH oxidase 5; ROS: Reactive oxygen species; PTEN: Phosphatase and tensin homolog; EGFR: Epidermal growth factor receptor; ROCK1: Rho-related kinase 1; SIRT1: Sirtuin 1; SPRY1: Sprouty homolog 1; AKAP12: A-kinase-anchoring protein 12; TLR4: Toll-like receptor 4; NF-κB: Nuclear factor-kappaB; PI3K: Phosphoinositide 3-kinase; eNOS: Endothelial nitric oxide synthase.