High doses of catecholamines activate glucose transport in human adipocytes independently from adrenoceptor stimulation or vanadium addition

Figure 6 Influence of insulin, β- and α-adrenergic receptor agonists on hexose transport in human adipocytes. 2-Deoxyglucose uptake assay was performed without (basal) and with 100 nmol/L insulin or 1 µmol/L of the indicated adrenergic receptor agonists. Dobutamine: β₁-AR agonist; procaterol: β₂-AR agonist; BRL 37344 and CL 316243: β₃-AR agonists; isoprenaline: pan-agonist of the three subtypes of β-ARs; UK 14304: α₂-AR agonist. Glucose transport was expressed as fold increase relative to basal uptake set at 1.0 (dotted line). Each column is the mean ± standard error of the mean of 9-12 individual adipocyte preparations. Only insulin-induced uptake was significantly different from baseline at: ^cP < 0.001. 2-DG: 2-Deoxyglucose.