Clinical significance of serum miR-129-5p in patients with diabetes mellitus presenting macrovascular complications

Table 1 Baseline characteristics of all participants

Parameter	Control (n = 36)	DM (n = 58)	DMC (n = 62)
Age (yr)	53.310 ± 1.535	55.860 ± 1.400	57.050 ± 1.190
Gender (male/female)	(13/23)	(32/26)	(33/29)
BMI (kg/m2)	24.150 ± 0.306	24.660 ± 0.388	25.050 ± 0.305
Duration of disease (yr)	-	5.376 ± 0.716	10.560 ± 1.230e
Systolic pressure (mmHg)	123.510 ± 2.039	134.703 ± 2.456b	137.712 ± 2.497c
Diastolic pressure (mmHg)	73.081 ± 1.704	82.261 ± 1.471c	81.732 ± 1.349c
OGTT (mmol/L)
Fasting glucose	5.397 ± 0.051	11.511 ± 0.597c	11.341 ± 0.709c
1-h glucose	8.835 ± 0.094	13.763 ± 0.596c	13.113 ± 0.339c
2-h glucose	6.568 ± 0.108	14.061 ± 0.622c	13.650 ± 0.483c
HbA1c, (%)	5.589 ± 0.111	10.64 ± 0.323c	10.290 ± 0.287c
Comprehensive metabolic indicators
TG (mmol/L)	1.335 ± 0.121	2.265 ± 0.2483b	1.867 ± 0.154a
TCHO (mmol/L)	4.792 ± 0.208	4.986 ± 0.153	5.047 ± 0.205
HDL-c (mmol/L)	1.410 ± 0.060	1.312 ± 0.049	1.303 ± 0.043
LDL-c (mmol/L)	2.831 ± 0.1643	3.566 ± 0.188b	3.735 ± 0.227b

^aP < 0.05.

^bP < 0.01.

^cP < 0.001, vs control.

^eP < 0.001, vs diabetes mellitus.

DM: Diabetes mellitus; DMC: Diabetic macrovascular complication; BMI: Body mass index; OGTT: Oral glucose tolerance test; HbA1c: Hemoglobin A1c; TG: Triglyceride; TCHO: Total cholesterol; HDL-c: High-density lipoprotein-cholesterol; LDL-c: Low-density lipoprotein-cholesterol.