Role of interferons in diabetic retinopathy

doi:10.4239/wjd.v12.i7.939

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jul 15, 2021; 12(7): 939-953
Published online Jul 15, 2021. doi: 10.4239/wjd.v12.i7.939

Table 3 Applications of interferon-α in ocular disorders

IFN	Clinical applications
IFN-α-2a	Ocular surface diseases: Tumors (such as limbal conjunctival melanoma, squamous neoplasias, and conjunctival MALT lymphoma)[134,137]; Mooren’s ulcers[138]; herpes simplex keratitis[139]
	Uveal disease: Behcet's uveitis[131]; serpiginous choroiditis[140]; choroidal neovascularization[141]; HHV-8-associated uveitis[142]; chronic noninfectious posterior uveitis[143]
	Macular and retinal disorders: Uveitic CME; angiogenesis after PRP; refractory non-infectious inflammatory macular edema[144]
IFN-α-2b	Ocular surface diseases: Tumors (such as squamous cell carcinoma[145], melanocytic tumors[145], CIN[146], conjunctival papillomatosis[147], and MALT lymphoma[57]); LSCD[135]; vernal keratoconjunctivitis[132]
	Uveal disease: Metastatic uveal melanoma[148]; Behcet's uveitis[149]
	Macular and retinal disorders: CME caused by intraocular infection[150]; refractory diabetic macular edema[133]
IFN-α-2	Dendritic keratitis[151]

MALT: Mucosa-associated lymphoid tissue; HHV-8: Human herpes virus 8; CME: Cystoid macular edema; PRP: Panretinal photocoagulation; CIN: Conjunctival and corneal intraepithelial neoplasia; LSCD: Limbal stem cell deficiency; IFN: Interferons.

Citation: Li BY, Tan W, Zou JL, He Y, Yoshida S, Jiang B, Zhou YD. Role of interferons in diabetic retinopathy. World J Diabetes 2021; 12(7): 939-953
URL: https://www.wjgnet.com/1948-9358/full/v12/i7/939.htm
DOI: https://dx.doi.org/10.4239/wjd.v12.i7.939