Role and function of granin proteins in diabetes mellitus

Table 2 Cleavage products of granin proteins[1,3,88-90]

Granin protein	Cleavage product
CgA1	Vasostatin-I (CgA1-76) and -II (CgA1-115)
	Betagranin (CgA1-128)
	CgA10-19 and CgA43-521
	Chromofungin (CgA47-66)
	Vasoconstriction-inhibiting factor (CgA79-113)
	Chromostatin (CgA124-143)
	Chromacin (CgA173-194)
	Pancreastatin (CgA250-301)1
	WE-14 (CgA324-337)1
	Cateslitin (CgA344-358)
	Catestatin (CgA352-372)1
	Parastatin (CgA357-428)
	GE-25 (CgA367-391)
	Serpinin (CgA417-442)
CgB1	CgB1-41
	GAWK (CgB420-493)
	BAM-1745 (CgB579-593)
	PE-11 (CgB555-565)
	Secretolytin (CgB647-657)
	43kDa large CgB fragment
SgII1	Secretoneurin (conjugate of SgII133-151 and SgII154-186)
	EM66 (66 amino acid long)
	Manserin (SgII497-536)
SgIII1	–2
HISL-19	–2
7B2	–2
NESP55	LSAL (NESP55159-162)
	GAIPIRRH (NESP55234-241)
VGF	Neuroendocrine regulatory peptide-1 (VGF281-306)
	Neuroendocrine regulatory peptide-2 (VGF310-347)
	NAPP129 or VGF20 (VGF417-617)
	TPGH (VGF422-430)
	TLQP-21 (VGF556-576)
	TLQP-62 or VGF10 (VGF556-617)
	HHPD-41 (VGF576-617)
	AQEE-11 (VGF588-599)
	AQEE-30 (VGF588-617)
	LQEQ-19 (VGF599-617)
proSAAS	KEP (proSAAS1-7)
	Big SAAS (proSAAS1-26)
	Little SAAS (proSAAS9-26)
	GAV
	PEN (proSAAS188-209)
	PEN-LEN (proSAAS188-227)
	Little LEN (proSAAS212-221)
	Big LEN (proSAAS212-227)

¹Granins and their cleavage products involved in carbohydrate metabolism.

²No cleavage product described to date. CgA: Chromogranin A; CgB: Chromogranin B; NESP55: Neuroendocrine secretory protein with an apparent molecular weight of 55000 Daltons; SgII: Secretogranin II.