Critical review of bone health, fracture risk and management of bone fragility in diabetes mellitus

doi:10.4239/wjd.v12.i6.706

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Jun 15, 2021 (publication date) through Nov 25, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jun 15, 2021; 12(6): 706-729
Published online Jun 15, 2021. doi: 10.4239/wjd.v12.i6.706

Table 3 Effects of osteoporosis medications in patients with type 2 diabetes mellitus

Medication	Effect on glucose metabolism	BMD	Risk of fracture
Alendronate	Reduction in the risk of diabetes	Increase	NA/unchanged
Risedronate	Reduction in the risk of diabetes	Increase	NA
Etidronate	NA	NA	Unchanged
Denosumab	No effect on blood glucoselevels	Increase	Decrease
Raloxifene	Improves insulin sensitivity	NA	Decrease/unchanged
Teriparatide	No effect blood glucose levels	Increase	Unchanged

BMD: Bone mineral density; NA: Not available.

Citation: Palui R, Pramanik S, Mondal S, Ray S. Critical review of bone health, fracture risk and management of bone fragility in diabetes mellitus. World J Diabetes 2021; 12(6): 706-729
URL: https://www.wjgnet.com/1948-9358/full/v12/i6/706.htm
DOI: https://dx.doi.org/10.4239/wjd.v12.i6.706