Diabetes-related intestinal region-specific thickening of ganglionic basement membrane and regionally decreased matrix metalloproteinase 9 expression in myenteric ganglia

Figure 6 The ratio of matrix metalloproteinase 9 and tissue inhibitor-labeling gold particles in myenteric ganglia of different gut segments of control, diabetic, and insulin-treated diabetic rats. In diabetic rats, the matrix metalloproteinase 9/tissue inhibitor of metalloproteinase 1 ratio was not altered in duodenal, but was markedly decreased in ileal ganglia. The immediate insulin replacement did not restore the equilibrium ratio observed in controls.