Maternal obesity as a risk factor for developing diabetes in offspring: An epigenetic point of view

Figure 2 Epigenetic programming mechanisms and offspring gene targets. Gene targets with epigenetic modifications in the offspring of obese mothers are indicated. Gene targets indicated with a question mark have been evidenced by maternal nutritional manipulations other than maternal obesity. ZFP423: Zinc finger protein 423; SCD1: Stearoyl-coenzyme A desaturase 1; PPAPγ: Peroxisome proliferator-activated receptor γ; GDF-3: Growth differentiation factor 3; RXR: Retinoid-X-receptor; IRS1: Insulin receptor substrate-1; HNF4α: Hepatocyte nuclear factor 4 α; Igf2: Insulin-like growth factor-2.