Causal effect of education on type 2 diabetes: A network Mendelian randomization study

Table 4 Causal association between genetically determined metabolic risk factors and type 2 diabetes mellitus

Trait	Method	nSNP	OR	95%CI		P value	Heterogeneity P	MR Egger intercept P
CHD-T2DM	MR Egger	28	0.947	0.697	1.288	0.733	0.000	0.815
	Weighted median	28	1.111	0.996	1.239	0.059
	Inverse variance weighted	28	1.073	0.954	1.207	0.243	0.000
BMI-T2DM	MR Egger	72	3.370	1.328	8.556	0.013	0.000	0.240
	Weighted median	72	2.622	2.164	3.178	0.000
	Inverse variance weighted	72	2.046	1.374	3.048	0.000	0.000
WC-T2DM	MR Egger	39	11.670	1.590	85.654	0.021	0.000	0.049
	Weighted median	39	2.371	1.788	3.145	0.000
	Inverse variance weighted	39	1.607	0.879	2.938	0.123	0.000

BMI: Body mass index; CHD: Coronary heart disease; MR: Mendelian randomization; OR: Odds ratio; nSNP: Number of single-nucleotide polymorphisms; T2DM: Type 2 diabetes mellitus; WC: Waist circumference.