Causal effect of education on type 2 diabetes: A network Mendelian randomization study

doi:10.4239/wjd.v12.i3.261

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World Journal of Diabetes

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World J Diabetes. Mar 15, 2021; 12(3): 261-277
Published online Mar 15, 2021. doi: 10.4239/wjd.v12.i3.261

Table 1 Details of studies and datasets used for analyses

Exposure/Outcome	Cases, n	Controls, n	Sample size	PubMed ID	First author	Consortium	Year	Units
Education (discovery data)	NA	NA	293723	27225129	Okbay	SSGAC	2016	SD (yr)
Education 2 (replication data)	NA	NA	226899	UKB-a:505	Neale	Neale Lab	2017	NA
T2DM	34840	114981	77312	22885922	Morris	DIAGRAM plus Metabochip	2012	Log odds
CHD	60801	123504	184305	26343387	Nikpay	CARDIoGRAM plus C4D	2015	Log odds
TG	NA	NA	108514	24097068	Willer	GLGC	2013	SD (mg/dL)
LDL	NA	NA	99073	24097068	Willer	GLGC	2013	SD (mg/dL)
TC	NA	NA	108363	24097068	Willer	GLGC	2013	SD (mg/dL)
BMI	NA	NA	152893	25673413	Locke	GIANT	2015	SD (kg/m²)
WC	NA	NA	232101	25673412	Shungin	GIANT	2015	SD (cm)
WHR	NA	NA	60586	23754948	Randall	GIANT	2013	SD (ratio)
Fasting insulin	NA	NA	38238	20081858	Dupuis	MAGIC	2010	Log pmol/L
Fasting glucose	NA	NA	58074	22581228	Manning	MAGIC	2012	mmol/L
HbA1c	NA	NA	46368	20858683	Soranzo	MAGIC	2010	%

BMI: Body mass index; CHD: Coronary heart disease; GIANT: Genetic Investigation of Anthropometric Traits; HbA1c: Glycated hemoglobin; LDL: Low-density lipoprotein; MAGIC: Mapping and Geographic Information Consortium; NA: Not available; SSGAC: Social Science Genetic Association Consortium; TC: Total cholesterol; T2DM: Type 2 diabetes mellitus; TG: Triglycerides; WC: Waist circumference; WHR: Waist-to-hip ratio.

Citation: Liao LZ, Chen ZC, Li WD, Zhuang XD, Liao XX. Causal effect of education on type 2 diabetes: A network Mendelian randomization study. World J Diabetes 2021; 12(3): 261-277
URL: https://www.wjgnet.com/1948-9358/full/v12/i3/261.htm
DOI: https://dx.doi.org/10.4239/wjd.v12.i3.261