Genome-wide association study reveals novel loci for adult type 1 diabetes in a 5-year nested case-control study

doi:10.4239/wjd.v12.i12.2073

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World Journal of Diabetes

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Dec 15, 2021; 12(12): 2073-2086
Published online Dec 15, 2021. doi: 10.4239/wjd.v12.i12.2073

Table 2 Identification of type 1 diabetes risk loci in a Chinese population

SNPs	Location	Stage	Genotype distribution		OR_add (95%CI)	P^a for Bonferroni
SNPs	Location	Stage	Cases (n = 785)	Controls (n = 804)	OR_add (95%CI)	P^a for Bonferroni
rs55846421	Chr14. 50310401	Discovery	10/149/222	0/6/371	0.024 (0.010-0.056)	4.28 × 10^-11
		Validation	8/124/272	2/37/385	0.232 (0.159-0.337)	8.73 × 10^-8
		Combination	18/273/494	2/43/756	0.113 (0.081-0.156)	1.76 × 10^-9
rs3117017	Chr6. 33095275	Discovery	2/40/339	36/117/224	4.958 (3.107-7.912)	6.36 × 10^-5
		Validation	6/32/365	32/98/297	3.202 (2.296-4.466)	4.51 × 10^-4
		Combination	8/72/704	68/215/521	3.794 (2.984-4.823)	9.33 × 10^-4
rs75836320	Chr12. 65156128	Discovery	8/77/296	1/12/356	0.153 (0.082-0.285)	0.011
		Validation	8/63/333	4/27/396	0.429 (0.289-0.638)	3.3 × 10^-4
		Combination	16/140/629	5/39/752	0.283 (0.205-0.392)	1.07 × 10^-4
rs362071	Chr22. 20811645	Discovery	82/193/104	46/101/230	0.445 (0.348-0.570)	4.5 × 10^-4
		Validation	100/173/131	79/149/199	0.705 (0.588-0.846)	0.0002
		Combination	182/366/235	125/250/429	0.568 (0.495-0.651)	1.66 × 10^-4

^aTwo-sided chi-square test. CI: Confidence interval; OR: Odds ratio.

Citation: Gao Y, Chen S, Gu WY, Fang C, Huang YT, Gao Y, Lu Y, Su J, Wu M, Zhang J, Xu M, Zhang ZL. Genome-wide association study reveals novel loci for adult type 1 diabetes in a 5-year nested case-control study. World J Diabetes 2021; 12(12): 2073-2086
URL: https://www.wjgnet.com/1948-9358/full/v12/i12/2073.htm
DOI: https://dx.doi.org/10.4239/wjd.v12.i12.2073