Thioredoxin interacting protein, a key molecular switch between oxidative stress and sterile inflammation in cellular response

Table 4 Summary of the in vitro Studies

Ref.	Cell type	Insult	TXNIP	NLRP3	CASP-1	IL-1β	TNF-a	NFKB	Casp-3	Other markers
Mohamed et al[2], 2015	EC	Palmitate	+	+	+	+			+	IL1-b in cell lysate and CM Adhesion Molecules
Mohamed et al[41], 2020	EC	TXNIP++		+	trend	+	+			Adhesion Molecules
Coucha et al[11], 2017	Muller	Palmitate	+ protein + mRNA	trend	trend	+				IL1-b in cell lysate
Coucha et al[33], 2019	Muller	Hypoxia	+ mRNA	trend	+	+				IL-1b in cell lysate
El-Azab et al[19], 2014		NMDA	+	+	+	+	+			IL1-b in CM
Gamdzyk et al[34], 2020	P12 cells	OGD	+			+	+			Cell death, miR-17-5p
Tian et al[81], 2012	Primary rat cortical neuron	OGD	+							Oxidative stress and activation of MAPK
Liu et al[97], 2020	Primary rat neurons	OGD	+	+	+	+				TXNIP NLRP3
Guo et al[3], 2018	SH-SY-5Y cells	OGD		+	+ activity	+				Activation of ER stress
Cao et al[43], 2016	bEnd.3	OGD	+	+	+					MAPK activation, EC-damage

TXNIP: Thioredoxin interacting protein; NLRP3: NOD-like receptor pyrin domain containing 3; ER: Endoplasmic reticulum; TNF-α: Tumor necrosis factor alpha; NMDA: N-methyl D-aspartate.