p66Shc-mediated oxidative stress is involved in gestational diabetes mellitus

Figure 2 Pathophysiological changes in placentas from women with and without gestational diabetes mellitus. A: Pathological changes in the placenta were observed by hematoxylin-eosin staining (× 100). The level of reactive oxygen species in the placentas was determined by dihydroethidium staining (× 100); B: Protein expression of p66Shc and dynamin-related protein 1 in placentas were determined by immunohistochemical staining (× 100). Drp1: Dynamin-related protein 1; GDM: Gestational diabetes mellitus; HE: Hematoxylin-eosin; ROS: Reactive oxygen species.