Profilin-1 is involved in macroangiopathy induced by advanced glycation end products via vascular remodeling and inflammation

Table 1 Comparison of clinical data (mean ± SD)

	Control group (n = 27)	CAD group (n = 31)	CAD+DM group (n = 31)
Age (yr)	60 ± 8	61 ± 9	64 ± 8
Sex (n)
Male	14	15	17
Female	13	16	14
Weight (kg)	60.87 ± 7.67	67.15 ± 12.00a	65.55 ± 10.30a
SBP (mmHg)	123.54 ± 14.28	126.41 ± 16.56	127.35 ± 19.49
DBP (mmHg)	74.46 ± 6.66	75.71 ± 10.45	78.74 ± 9.57
FPG (mmol/L)	4.86 ± 0.56	5.47 ± 0.87	9.92 ± 3.26a,c
HbA1c (%)	4.90 ± 0.58	6.07 ± 0.93a	7.43 ± 1.70a,c
GSP (mmol/L)	1.81 ± 0.19	2.27 ± 0.39	2.78 ± 1.19a,c
TG (mmol/L)	1.21 ± 0.35	1.79 ± 1.25a	2.44 ± 2.15a,c
TC (mmol/L)	2.10 ± 1.61	4.40 ± 1.08a	4.51 ± 1.26a
LDL-C (mmol/L)	2.32 ± 0.53	2.63 ± 0.67	2.59 ± 1.22
HDL-C (mmol/L)	1.35 ± 0.31	2.48 ± 1.43	1.50 ± 1.14
hs-CRP (mg/L)	1.34 ± 0.61	3.84 ± 3.15a	4.65 ± 2.70a
BUN (mmol/L)	5.29 ± 0.73	5.53 ± 1.44a	5.85 ± 1.65a
SCr (μmol/L)	79.3 ± 15.2	82.3 ± 23.3	93.2 ± 21.4a,c
SUA (mmol/L)	309.2 ± 92.3	316.3 ± 81.7	327.6 ± 69.8

^aP < 0.05 compared with the control group.

^cP < 0.05 compared with the coronary artery disease group.

CAD: Coronary artery disease; DM: Diabetes mellitus; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; FPG: Fasting plasma glucose; HbA1c: Glycosylated hemoglobin; GSP: Glycosylated serum protein; TG: Triglyceride; TC: Total cholesterol; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; hsCRP: High sensitivity C-reactive protein; BUN: Serum urea nitrogen; Scr: Serum creatinine; SUA: Serum uric acid.