Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin

Figure 5 Double-knockout mice have increased peritoneal and adipose tissue inflammation compared to cannabinoid type 1 receptor-null mice. Cannabinoid type 1 receptor-null (CB1^-/-) and double-knockout (DKO) male mice at 7 mo of age. A: Flow cytometry analysis of M1 and M2 macrophages of peritoneal macrophages; B: Epididymal weight and percentage of epididymal depot; C: Flow cytometry analysis of M1 and M2 in stromal vascular fraction of epididymal fat; D: Pro-inflammatory cytokines expression of epididymal fat. n = 6-7. ^aP < 0.05, ^bP < 0.001, CB1^-/- vs DKO mice.