Metabolic and inflammatory functions of cannabinoid receptor type 1 are differentially modulated by adiponectin

Figure 1 Cannabinoid type 1 receptor-null mice have reduced adiposity and improved insulin sensitivity. Wild-type (WT) and cannabinoid type 1 receptor-null (CB1^-/-) male mice at 4 mo of age. A: Body weight and body composition; B: Daily food intake; C: Locomotor activity; D: Energy expenditure adjusted by body weight or lean mass; E: Insulin tolerance tests; F: Glucose tolerance tests at 5 mo of age. n = 5-7. ^aP < 0.05, ^bP < 0.001, WT vs CB1^-/-.