Diabetic kidney disease: Are the reported associations with single-nucleotide polymorphisms disease-specific?

Table 3 Associations between genetic risk score and different parameters in diabetic kidney disease and non-diabetic kidney disease patients

Parameter	DKD + NDKD, n = 227		DKD, n = 117		NDKD1, n = 91
	GRS, mean ± SD	P value	GRS, mean ± SD	P value	GRS, mean ± SD	P value
Rapid progression (TTD ≤ 3 mo vs > 3 mo)	0.602 ± 0.233 vs 0.603 ± 0.258	0.99	0.518 ± 0.273 vs 0.620 ± 0.260	0.34	0.687 ± 0.167 vs 0.574 ± 0.248	0.27
Fast progression (TTD ≤ 1 yr vs > 1 yr)	0.592 ± 0.246 vs 0.606 ± 0.260	0.75	0.600 ± 0.229 vs 0.620 ± 0.270	0.71	0.522 ± 0.253 vs 0.593 ± 0.242	0.30
Slow progression (TTD > 5 yr vs ≤ 5 yr)	0.596 ± 0.256 vs 0.607 ± 0.258	0.77	0.629 ± 0.286 vs 0.608 ± 0.249	0.69	0.583 ± 0.230 vs 0.580 ± 0.257	0.96
Diuresis (preserved diuresis vs no diuresis)	0.614 ± 0.260 vs 0.557 ± 0.239	0.18	0.622 ± 0.265 vs 0.578 ± 0.235	0.49	0.605 ± 0.244 vs 0.503 ± 0.235	0.09
24h diuresis > 500 mL (> 500 mL vs ≤ 500 mL)	0.630 ± 0.244 vs 0.583 ± 0.265	0.17	0.621 ± 0.258 vs 0.611 ± 0.263	0.83	0.643 ± 0.220 vs 0.535 ± 0.253	0.035
Male sex (males vs females)	0.639 ± 0.265 vs 0.591 ± 0.255	0.31	0.617 ± 0.263 vs 0.586 ± 0.249	0.37	0.589 ± 0.251 vs 0.568 ± 0.235	0.70

¹Cases with complex pathogenesis excluded from analysis.

DKD: Diabetic kidney disease; NDKD: Non-diabetic kidney disease; GRS: Genetic risk score; TTD: Time-to-dialysis (time between the diagnosis of chronic kidney disease and start of hemodialysis). Significant differences are highlighted in bold.