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Copyright ©The Author(s) 2021.
World J Diabetes. Oct 15, 2021; 12(10): 1704-1718
Published online Oct 15, 2021. doi: 10.4239/wjd.v12.i10.1704
Table 3 Alterations in Ca2+/calmodulin-dependent protein kinase II in experimental models of pre-diabetes induced by diet
Experimental modelCaMKII alterationsFunctional effectsRef.
Sucrose-fed Sprague-Dawley rats (32% 10 wk)↑ CaMKII activity (autocamtide phosphorylation)↓ PLN-Thr17 phosphorylationVasanji et al[52]
Fructose-fed Wistar rats (10%, 3 wk)↑ CaMKII oxidation; ↔ CaMKII expression↑ RyR2-Ser2814 phosphorylationSommese et al[55]
Sucrose-fed Wistar rats (30%, 4 mo)↑ CaMKII-Thr287 phosphorylation; ↔ CaMKII expression↑ RyR2-Ser2814 phosphorylationRomero-García et al[48]
HFD Long-Evans rats treated with STZ (40% lard, 21 wk)↔ CaMKII-Thr287 phosphorylation; ↔ CaMKII expression↔ PLN-Thr17 phosphorylationKoncsos et al[62]