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Copyright ©The Author(s) 2021.
World J Diabetes. Oct 15, 2021; 12(10): 1704-1718
Published online Oct 15, 2021. doi: 10.4239/wjd.v12.i10.1704
Table 2 Alterations in protein kinase A in experimental models of pre-diabetes induced by diet
Experimental model
Kinase modification
Functional effects
Ref.
HFD dogs (80% of calories from fat, 5 wk)ND↑ RyR2- Ser2809 phosphorylationDincer et al[73]
Sucrose-fed Sprague-Dawley rats (32%, 10 wk)↑ PKA activity (kemptide phosphorylation)↓ PLN-Ser16 phosphorylationVasanji et al[52]
Sucrose-fed Wistar rats (30%, 35 wk)↔ expression and activity↔ PLN-Ser16 phosphorylation; ↓ RyR2- Ser2808 phosphorylationPaulino et al[65]
Sucrose-fed Wistar rats (32%, 16 wk)↑ PKA activity (Thr198 phosphorylation)↑ RyR2- Ser2808 phosphorylation; ↓ PLN-Ser16 phosphorylationOkatan et al[28]
Fructose-fed Wistar rats(10%, 3 wk)ND↔ RyR2- Ser2808 phosphorylationSommese et al[55]
HFD Long-Evans rats treated with STZ (40% lard, 21 wk)ND↔ PLN-Ser16 phosphorylationKoncsos et al[62]
HFD C57bl/6 mice (60% of calories from fat, 8 wk)ND↔ RyR2- Ser2808 phosphorylation; ↔ PLN-Ser16 phosphorylationSánchez et al[63]
Sucrose-fed Wistar rats (30%, 24 wk)ND↔ RyR2- Ser2808 phosphorylation; ↔ PLN-Ser16 phosphorylationFernández-Miranda et al[70]
Sucrose-fed Wistar rats (30%, 4 mo)ND↔ RyR2- Ser2808 phosphorylation; ↔ PLN-Ser16 phosphorylationRomero-García et al[48]
HFD C57bl/6N mice (45% of total calories from fat, 8 wk)ND↔ PLN-Ser16 phosphorylationLlano-Diez et al[79]