Novel glucose-lowering drugs for non-alcoholic fatty liver disease

Table 4 Comparison of magnetic resonance imaging proton density fat fraction and visceral fat area change from baseline in different treatment groups

	Studies	Participants	WMD	95%CI		P value
MRI-PDFF change
DPP-4 inhibitors	2	52/49	-2.31	-4.92	0.29	0.08
GLP-1 RAs	1	24/24	-3.20	-5.98	-0.42	0.02
SGLT2 inhibitors	2	65/61	-1.18	-2.38	0.03	0.06
VFA change
DPP-4 inhibitors	1	27/24	-23.10	-38.84	-7.36	0.004
GLP-1 RAs	1	24/24	-30.40	-46.86	-13.94	0.0003
SGLT2 inhibitors	2	48/50	-23.48	-25.85	-21.12	< 0.0001

MRI-PDFF: Magnetic resonance imaging proton density fat fraction; VAF: Visceral fat area; WMD: Weighted mean difference; CI: Confidence interval; DPP-4: Dipeptidyl peptidase-4; GLP-1 RA: Glucagon-like peptide-1 receptor agonist; SGLT2: Sodium-glucose cotransporter 2.