Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

doi:10.4239/wjd.v12.i1.19

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Jan 15, 2021 (publication date) through Nov 5, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jan 15, 2021; 12(1): 19-46
Published online Jan 15, 2021. doi: 10.4239/wjd.v12.i1.19

Table 4 Comparison of expression of tenascin-C, creatinine, and urea nitrogen in serum of rats [mean ± SD, M (quartile)]

Group	n	TNC (ng/mL)	Creatinine (mmol/L)	Urea nitrogen (mmol/L)
N	6	40.85 ± 2.99	37.27 ± 6.41	6.02 ± 1.57
D	6	59.25 ± 3.46^a	129.08 ± 39.88^a	22.48 ± 2.71

^aP < 0.05 compared with group. N, n = 6 for each group. N: Normal rat serum; D: Diabetic rat serum; TNC: Tenascin-C.

Citation: Zhou Y, Ma XY, Han JY, Yang M, Lv C, Shao Y, Wang YL, Kang JY, Wang QY. Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop. World J Diabetes 2021; 12(1): 19-46
URL: https://www.wjgnet.com/1948-9358/full/v12/i1/19.htm
DOI: https://dx.doi.org/10.4239/wjd.v12.i1.19