Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop

doi:10.4239/wjd.v12.i1.19

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Jan 15, 2021 (publication date) through Nov 5, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jan 15, 2021; 12(1): 19-46
Published online Jan 15, 2021. doi: 10.4239/wjd.v12.i1.19

Table 3 Correlation between tenascin-C levels and urinary albumin excretion rate

Index	lgTNC
Index	β	t	P value
Constant	0.0001	-31.965	0.001
lgHbA_1c	0.405	15.893	0.001
BMI	0.110	4.090	0.002
SBP	0.341	13.379	0.002
lgUACR	0.131	4.621	0.001

BMI: Body mass index; SBP: Systolic blood pressure; 1 mmHg = 0.133 kPa; UACR: Urinary albumin to creatinine ratio; TNC: Tenascin-C.

Citation: Zhou Y, Ma XY, Han JY, Yang M, Lv C, Shao Y, Wang YL, Kang JY, Wang QY. Metformin regulates inflammation and fibrosis in diabetic kidney disease through TNC/TLR4/NF-κB/miR-155-5p inflammatory loop. World J Diabetes 2021; 12(1): 19-46
URL: https://www.wjgnet.com/1948-9358/full/v12/i1/19.htm
DOI: https://dx.doi.org/10.4239/wjd.v12.i1.19