Relationship between diabetic polyneuropathy, serum visfatin, and oxidative stress biomarkers

Table 1 The median of the parameters and the correlation between neuropathy clinical scores and biochemical parameters, visfatin, and oxidative stress biomarkers

	SPNSQ score, 5.66 ± 3.64	MNSI q, 4.5 ± 2.28	MNSI exam, 2.42 ± 1.99
Glucose, mg/dL, 154.0 ± 57.5	P = 0.099, r = 0.084	P = 0.110, r = 0.081	P = 0.110, r = 0.081
HbA1c, 7.68 ± 1.52	P = 0.099, r = 0.084	P = 0.062, r = 0.094	bP < 0.01, r = 0.170
Creatinine, mg/dL, 0.81 ± 0.13	P = 0.017, r = -0.121	P = 0.053, r = -0.098	P = 0.143, r = 0.074
ALT, U/L, 22.3 ± 12.8	P = 0.177, r = 0.000	P = 0.518, r = 0.033	P = 0.585, r = 0.028
AST, U/L, 18.6 ± 7.8	P = 0.587, r = 0.028	P = 0.676, r = 0.021	P = 0.810, r = -0.012
LDL cholesterol, mg/dL, 118.12 ± 28.00	P = 0.077, r = 0.090	P = 0.151, r = 0.073	P = 0.868, r = 0.008
Triglycerides, mg/dL, 160.3 ± 85.0	P =0.123, r = 0.078	P = 0.355, r = 0.047	P = 0.994, r = 0.000
Vitamin B12, pg/mL, 425.5 ± 32.0	aP < 0.05, r = 0.132	P = 0.062, r = 0.095	P = 0.049, r = 0.100
Visfatin, pg/mL, 19.34 ± 8.07	P = 0.579, r = 0.028	P = 0.330, r = 0.049	aP < 0.05, r = 0.122
TOS, μmol H2O2/L, 12.91 ± 1.92	P = 0.417, r = 0.041	P = 0.340, r = 0.048	aP < 0.05, r = 0.155
TAS, mmol Trolox Eq./L, 0.87 ± 0.14	P = 0.385, r = 0.044	P = 0.160, r = -0.071	aP < 0.05, r = -0.127
OSI (Arbitrary units), r = 0.20, 15.29 ± 4.12	P = 0.283, r = 0.054	P = 0.170, r = 0,069	bP < 0.01, P = 0.000
Total thiol, mmol/L, 0.51 ± 0.05	P = 0.070, r = -0.092	P = 0.053, r = -0.098	P = 0.251, r = -0.05
Native thiol, mmol/L, 0.35 ± 0.05	P = 0.822, r = 0.011	P = 0.903, r = -0.006	P = 0.864, r = -0.009
Thiol-disulfide, mmol/L, 0.08 ± 0.03	P = 0.059, r = -0.096	P = 0.069, r = -0.092	P = 0.270, r = -0.056

^aP < 0.05,

^bP < 0.01. SPNSQ: Subjective Peripheral Neuropathy Screen Questionnaire; MNSI q: Michigan Neuropathy Screening Instrument questionnaire; MNSI exam: Michigan Neuropathy Screening Instrument examination; HbA1c: Glycosylated hemoglobin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; TOS: Total oxidant status; TAS: Total antioxidant status; OSI: Oxidative stress index; LDL: Low density lipoprotein.