CD47 decline in pancreatic islet cells promotes macrophage-mediated phagocytosis in type I diabetes

doi:10.4239/wjd.v11.i6.239

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Jun 15, 2020 (publication date) through Nov 7, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jun 15, 2020; 11(6): 239-251
Published online Jun 15, 2020. doi: 10.4239/wjd.v11.i6.239

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Figure 2 Macrophage phagocytosis assay in vitro. A and B: Flow cytometry results displayed declined CD47 expression of Min6 cells. C: Insulin secretion decreased with STZ stimulation. D: More LPS activated macrophages were recruited to phagocyte CD47 down-regulated Min6 cells. Arrows indicate phagocytosis. Student's t-test was performed. ^aP < 0.01 vs CTL. CD47: Cluster of differentiation 47; STZ: Streptozotocin; CFSE: Carboxy fluorescein succinimidyl ester.

Citation: Zhang J, Tan SB, Guo ZG. CD47 decline in pancreatic islet cells promotes macrophage-mediated phagocytosis in type I diabetes. World J Diabetes 2020; 11(6): 239-251
URL: https://www.wjgnet.com/1948-9358/full/v11/i6/239.htm
DOI: https://dx.doi.org/10.4239/wjd.v11.i6.239