CD47 decline in pancreatic islet cells promotes macrophage-mediated phagocytosis in type I diabetes

Figure 1 Increased macrophage migration to pancreatic islet cells with the reduction of CD47 expression under streptozotocin treatment. A: The experimental design. Mice were treated by five daily intraperitoneal injections of streptozotocin (STZ) to construct a diabetes model; B: Macrophage infiltration into pancreatic islet cells which was indicated by increased F4/80 labeling accompanied by decreased insulin secretion in STZ treated cells; C: Statistical data; D and E: CD47 expression decreased under STZ condition. Student's t-test was performed. ^aP < 0.01 vs CTL. CD47: Cluster of differentiation 47; STZ: Streptozotocin; CFSE: Carboxy fluorescein succinimidyl ester.