Fundamentals about onset and progressive disease character of type 2 diabetes mellitus

Table 1 Short summary of different definitions of the term: Insulin resistance

	Ref.
Insulin resistance is the impaired sensitivity of tissue to the action of insulin	[5]
Insulin resistance signifies the inability of insulin at physiological concentrations to exert its normal metabolic actions.	[6]
Insulin resistance is a diminished ability to keep the serum glucose low with insulin levels in the normal range.	[7]
Insulin resistance is an integral concept characterizing all cases of a reduced biological effect of insulin with its normal concentration and activity.	[8]
Insulin resistance is defined as a state of reduced responsiveness to normal circulating concentrations of insulin.	[9]
Insulin resistance refers to state in which physiological concentrations of insulin are poorly effective.	[10]
Insulin resistance is characterized by a reduced sensitivity of body cells to the actions of insulin.	[11]
Insulin resistance is defined as the inability of cells to efficiently respond to stimulation by insulin.	[12]