Lack of Syndecan-1 produces significant alterations in whole-body composition, metabolism and glucose homeostasis in mice

Figure 5 Syndecan-1 knockout mice have decreased locomotor activity. Mice were fed with chow or high-fat diet as described previously and physical activity (x-axis infrared beam array) was measured using the Oxymax/CLAMS system. A: The data were reported every 25 min throughout the studies, and are presented as 24-h sums; B: Sums for the 12-h dark; C: Light phases. Data represents mean ± SE of total 12 animals of each genotype. Statistical analysis was performed using the two-tailed student’s t-test. ^aP < 0.05. Sdc1 KO: Sdc1 knockout; HFD: High-fat diet; WT: Wild type.