Lack of Syndecan-1 produces significant alterations in whole-body composition, metabolism and glucose homeostasis in mice

Figure 3 O₂ consumption and energy expenditure throughout light and dark phase in syndecan-1 knockout and wild type mice on chow-diet. Mice on the chow and high-fat diet were kept over 8 wk and then indirect calorimetry was performed using the Oxymax/CLAMS system. Each day O₂ consumption (VO₂) and energy expenditure was monitored in individual 8-wk-old mice of each genotypes. A: Measurements were performed over 4 consecutive days following a 24-h acclimation period and are shown as total energy expenditure and VO₂; B: Respiratory exchange ratio and VO₂ is presented as the average for the dark; C: Light phases. Data represents mean ± SE of total 12 animals of each genotype. Statistical analysis was performed using the two-tailed student’s t-test. ^cP < 0.001, ^bP < 0.01, ^aP < 0.05. Sdc1 KO: Sdc1 knockout; WT: Wild type.