Long-term effect of clopidogrel in patients with and without diabetes: A systematic review and meta-analysis of randomized controlled trials

Table 3 Baseline characteristics of participants in the included trials

Trial	Country	Centers	Patients	Sample size	Male %	Mean age Y	Diabetes%	Treatment duration M	Lost to follow-up %	Blinding	ITT analysis
CHANCE 2013	China	114	Minor ischemic stroke or high-risk TIA	5170	66	63	21	3	0.7	Double-blind	Yes
CHARI-SM 2006	Worldwide	768	CVD or multiple risk factors	15603	70	64	42	28	0.5	Double-blind	Yes
CREDO 2002	United States and Canada	99	Those would undergo elective PCI	2116	71	62	26	12	1.1	Double-blind	Yes
CURE 2001	Worldwide	482	ACS without ST-segment elevation	12562	62	64	23	12	0.1	Double-blind	Yes
POINT 2018	Worldwide	269	Acute ischemic stroke or high-risk TIA	4881	55	65	27	3	4.1	Double-blind	Yes
SPS3 2012	Worldwide	82	Recent symptomatic lacunar infarcts	3020	63	63	36	41	2.0	Double-blind	Yes

ITT: Intention-to-treat; TIA: Transient ischemic attack; CVD: Cardiovascular disease; PCI: Percutaneous coronary intervention; ACS: Acute coronary syndromes.