Vanadium-dependent activation of glucose transport in adipocytes by catecholamines is not mediated via adrenoceptor stimulation or monoamine oxidase activity

Figure 9 Glucose transport activation by insulin, adrenaline and noradrenaline in adipocytes from mice expressing or lacking β-adrenoceptors. Left panel: Insulin dose-dependent stimulation of 2-deoxyglucose uptake in adipocytes from wild-type (control, black symbols) and "β-less" mice lacking β₁-, β₂-, β₃-adrenoceptors (triple KO, open symbols). Right panel: Stimulation of hexose uptake by adrenaline (adre, squares) and noradrenaline (noradr, triangles) in the presence of 100 µmol/L vanadate (orange arrow). The mean ± SE of 4 (triple KO, dotted lines) to 13 (control, solid lines) adipocyte preparations was determined. A significant difference from the corresponding control was observed at: ^aP < 0.05. 2-DG: 2-Deoxyglucose.