Factors associated with improvement in waist-to-height ratio among newly diagnosed type 2 diabetes patients treated with acarbose or metformin: A randomized clinical trial study

Table 3 Changes in key endpoints from baseline to week 24 of patients in different change of waist-to-height ratio groups treated with acarbose

	High ΔWHtR	Lower ΔWHtR	P value
Anthropometric measurements
Body weight, kg	-3.63 (-4.08 to -3.18)	-1.29 (-1.81 to -0.79)	< 0.001
Body mass index, kg/m2	-1.60 (-1.79 to -1.41)	-0.56 (-0.72 to -0.39)	< 0.001
Waist circumference, cm	-5.57 (-6.05 to -5.09)	0.87 (-0.42 to 1.32)	< 0.001
Hip circumference	-4.49 (-5.22 to -3.77)	-0.13 (-0.72 to 0.45)	< 0.001
Glucose metabolism variables
HbA1c, %	-1.19 (-1.36 to -1.01)	-1.11 (-1.32 to -0.90)	0.511
FPG, mmol/L	-1.47 (-1.67 to -1.27)	-1.10 (-1.35 to 0.84)	0.024
PPG, mmol/L	-3.21 (-3.62 to -2.81)	-2.82 (-3.32 to -2.32)	0.546
Blood pressure and lipid profile
Systolic blood pressure, mmHg	-2.11 (-3.97 to -0.25)	-0.42 (-2.29 to 1.44)	0.207
Diastolic blood pressure, mmHg	-1.79 (-3.26 to -0.32)	-2.35 (-3.63 to -1.07)	0.574
TC, mmol/L	-0.48 (-0.62 to 0.34)	-0.27 (-0.43 to 0.12)	0.103
HDL-C, mmol/L	0.07 (-0.03 to 0.11)	-0.01 (-0.05 to 0.03)	0.012
LDL-C, mmol/L	-0.22 (-0.34 to -0.09)	-0.07 (-0.20 to 0.07)	0.158
NHDL-C, mmol/L	-0.55 (-0.69 to -0.41)	-0.27 (-0.42 to -0.11)	0.021
HDL-C/NHDL-C	0.08 (0.06 to 0.10)	0.03 (0.01 to 0.05)	< 0.001
TG, mmol/L	-0.62 (-0.87 to -0.37)	-0.90 (-0.42 to -0.07)	0.562
Hormones and insulin sensitivity
HOMA-β	-0.58 (-10.07 to 8.92)	10.09 (-13.30 to 33.49)	0.195
I30/G30	-0.02 (-2.93 to 2.90)	1.43 (-0.09 to 2.95)	0.012
FINS, μIU/mL	-4.73 (-6.27 to -3.19)	-2.88 (-4.80 to -0.95)	0.012
AUCinsulin, μIU/L × min	-1.47 (-1.86 to -1.07)	-0.794 (-1.16 to -0.43)	0.092
AUCGLP-1, nmol × min	1.41 (1.04 to 1.78)	0.65 (1.87 to 1.11)	0.002
HOMAIR	-2.30 (-2.87 to -1.74)	-1.53 (-2.19 to -0.87)	0.003
WBISI	69.38 (56.59 to 82.17)	47.78 (34.63 to 60.93)	0.610

WHtR: Change of waist-to-height ratio; TC: Total cholesterol; LDL-C: Low-density lipoprotein cholesterol; HDL-C: High-density lipoprotein cholesterol; TG: Triglycerides; HDL-C/non-HDL-C: HDL-C-to-non-HDL-C ratio; FPG: Fasting plasma glucose; PPG: Postprandial plasma glucose; FINS: Fasting plasma insulin; HOMA: Homeostasis model assessment; IR: Insulin resistance; WBISI: Whole body insulin sensitivity index; AUC: Area under the curve; GLP-1: Glucagon-like peptide 1.