Continuous glucose monitoring defined time-in-range is associated with sudomotor dysfunction in type 2 diabetes

Table 4 Association between tertiles of time in range and sudomotor dysfunction

		OR	95%CI	P value
Model 1
TIR T1	-	-	-	-
TIR T2	-1.175	0.309	0.183-0.521	< 0.001
TIR T3	-0.961	0.383	0.225-0.649	< 0.001
Age	0.022	1.022	1.002-1.044	0.035
Smoking	0.600	1.823	1.085-3.063	0.023
Model 2
TIR T1	-	-	-	-
TIR T2	-1.241	0.289	0.164-0.509	< 0.001
TIR T3	-1.032	0.356	0.189-0.673	0.001
Age	0.022	1.022	1.001-1.044	0.036
Smoking	0.608	1.837	1.092-3.091	0.022
Model 3
TIR T1	-	-	-	-
TIR T2	-0.809	0.445	0.209-0.948	0.036
TIR T3	-1.141	0.320	0.123-0.831	0.019
Age	0.029	1.030	1.007-1.053	0.011
Smoking	0.670	1.953	1.100-3.468	0.022
M value	0.111	1.117	1.057-1.180	< 0.001

Time in range T1: < 55.69%; T2: 55.69%-79.86%; T3: > 79.86%. Model 1 was adjusted for age, diabetes duration, sex, body mass index, systolic blood pressure, diastolic blood pressure, smoking, triglyceride, and total cholesterol. Model 2 was adjusted for variables as in model 1 and for HbA1c. Model 3 was adjusted for variables as in model 2 and for glycemic variability metrics like standard deviation, mean amplitude of glucose excursions, means of daily differences, average daily risk range, and M value. TIR: Time in range; CI: Confidence interval.