Bone health in diabetes and prediabetes

doi:10.4239/wjd.v10.i8.421

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Aug 15, 2019; 10(8): 421-445
Published online Aug 15, 2019. doi: 10.4239/wjd.v10.i8.421

Table 1 Bone turnover markers in prediabetes/insulin resistance and type 2 diabetes

BTM	Meaning	Pre-DM / IR	Ref.	T2D	Ref.
CTX	Bone resorption	↓ or ↔	[136,276,278-280]	↓	[129,132,134,137,281-286]
TRAP	Bone resorption	↑?	[287]	↓ or ↔	[132,281]
uNTX	Bone resorption			↓	[285]
Sclerostin	Inhibition of bone formation	↑	[65]	↑	[284,285,288,289]
OC	Bone formation	↓ or ↔	[128,276-278,280,290]	↓ or ↔	[129,132,134,281,283,285,286,291-294]
P1NP	Bone formation	↓ or ↔	[136,277,280]	↓ or ↔	[88,132,134,137,282,283,285,286]
BAP	Bone formation	Direct association with IR	[295]	↔ or ↓ or ↑	[132,281,284,286,292,294]
ALP	Bone formation	?	^?	↔ or ↑	[292-294]
OPG	Inhibition of bone resorption	↑	[296]	↑	[293,296]

BTM: Bone turnover marker; pre-DM: Prediabetes; IR: Insulin resistance; T2D: Type 2 diabetes; CTX: Carboxy-terminal cross-linking telopeptide of type I collagen; OC: Osteocalcin; P1NP: Procollagen type 1 amino-terminal propeptide; TRAP: Tartrate-resistant acid phosphatase; uNTX: Urinary N-telopeptide of type I collagen; BAP: Bone-specific alkaline phosphatase; ALP: Alkaline phosphatase; OPG: Osteoprotegerin; ↑: Increased; ↓: Decreased; ↔: Similar to healthy controls; ?: Unknown.

Citation: Costantini S, Conte C. Bone health in diabetes and prediabetes. World J Diabetes 2019; 10(8): 421-445
URL: https://www.wjgnet.com/1948-9358/full/v10/i8/421.htm
DOI: https://dx.doi.org/10.4239/wjd.v10.i8.421