Pharmacologic adjunctive to insulin therapies in type 1 diabetes: The journey has just begun

doi:10.4239/wjd.v10.i4.234

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Apr 15, 2019 (publication date) through Dec 1, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Apr 15, 2019; 10(4): 234-240
Published online Apr 15, 2019. doi: 10.4239/wjd.v10.i4.234

Table 2 Main limitations of available evidence on the use of various drugs as adjunctive treatments in type 1 diabetes

Limitations of clinical trials	Small number of studies and patients involved
	Heterogeneity in study designs and explored outcomes
	“Conventional” outcomes explored: changes in HbA1_C, body weight and insulin dose. Data on glycemic variability, IR and OS markers are scarce
	Not taking into account the clinical heterogeneity of patients with T1D
	Trials exploring the effects of adjunctive treatments on “hard” CVD end points in T1D patients are currently unavailable

HbA1_C: Glycated hemoglobin A1_C; T1D: Type 1 diabetes; CVD: Cardiovascular disease; IR: Insulin resistance; OS: Oxidative stress.

Citation: Karras SN, Koufakis T, Zebekakis P, Kotsa K. Pharmacologic adjunctive to insulin therapies in type 1 diabetes: The journey has just begun. World J Diabetes 2019; 10(4): 234-240
URL: https://www.wjgnet.com/1948-9358/full/v10/i4/234.htm
DOI: https://dx.doi.org/10.4239/wjd.v10.i4.234