Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia

Table 4 Genetic ancestry for type 1 diabetes patients stratified according to age at onset

Chromosomal region	Ancestry	Early age at onset, ≤ 5 yr	Late age at onset, > 5 yr	P value1
Overall AIMs	EUR	62.06 (54.50-71.38)	61.12 (51.66-68.68)	0.420
	NAT	25.40 (18.14-33.55)	27.75 (21.86-34.35)	0.345
	AFR	11.09 (3.90-17.25)	10.19 (3.88-16.91)	0.927
Chr2_EFR3B	EUR	57.65 (34.05-82.17)	62.45 (42.04-80.67)	0.419
	NAT	25.16 (1.27-52.11)	24.30 (0.01-51.73)	0.607
	AFR	5.02 (0.01-27.29)	7.37 (0.01 23.32)	0.941
Chr2_CTLA4	EUR	58.49 (24.63-78.80)	46.09 (12.90-66.30)	0.180
	NAT	26.28 (3.98-39.82)	30.19 (4.55-42.10)	0.362
	AFR	18.05 (0.01-37.80)	20.68 (0.01-41.72)	0.701
Chr2_RNASEH1	EUR	56.84 (44.50-72.18)	56.91 (28.02-74.15)	0.672
	NAT	27.22 (0.01-31.22)	28.03 (8.15-48.58)	0.472
	AFR	3.38 (0.01-31.22)	8.62 (0.01-27.20)	0.917
Chr2_IFIH1	EUR	41.35 (0.01-66.94)	42.42 (4.44-76.73)	0.126
	NAT	33.05 (0.67-57.49)	29.05 (0.01-53.09)	0.339
	AFR	14.57 (0.01-42.31)	1.01 (0.01-42.31)	0.796
Chr5_IL7R	EUR	9.38 (0.33-41.70)	12.86 (1.73-43.11)	0.338
	NAT	53.83 (39.76-99.60)	50.94 (30.21-88.75)	0.197
	AFR	6.17 (1.01-29.03)	19.96 (9.6-37.36)	0.023
Chr6_MHC	EUR	51.67 (32.23-63.29)	52.07 (34.26-71.84)	0.596
	NAT	30.57 (13.47-43.21)	26.71 (7.69-37.39)	0.480
	AFR	15.03 (4.46-36.05)	20.52 (1.08-36.73)	0.118
Chr10_NRP1	EUR	63.32 (23.70-63)	63.32(43.07-69.08)	0.357
	NAT	36.68 (7.93-36.67)	36.67 (7.93-36.68)	0.797
	AFR	0.16 (0.001-39-1)	0.38 (0.001-63.3)	0.498

¹Mann-Whitney U test. AIMs: Ancestry informative markers; IQR: Interquartile Range; Chr2: Chromosome 2; Chr6: Chromosome 6; EUR: European; NAT: Native American; AFR: African.