Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia

Table 3 Genetic ancestry for type 1 diabetes patients stratified according to autoimmunity

Chromosomal region	Ancestry	T1AD, median (IQR)	T1BD, median (IQR)	P value1
Overall AIMs	EUR	61.92 (53.57-70.89)	59.79 (49.70-68.03)	0.333
	NAT	27.07 (20.82-33.48)	29.16 (21.57-37.06)	0.312
	AFR	10.19 (2.88-16.01)	11.54 (5.55-17.80)	0.344
Chr2_EFR3B	EUR	60.28 (36.24-83.66)	59.79 (32.34-80.01)	0.551
	NAT	25.16 (0.01-51.24)	21.92 (0.01-45.95)	0.979
	AFR	4.53 (0.01-23.32	14.41 (0.01-27.36)	0.119
Chr2_CTLA4	EUR	53.34 (16.82-70.53)	41.16 (16.62-60.86)	0.231
	NAT	26.28 (4.55-41.31)	32.69 (9.35-50.25)	0.343
	AFR	20.54 (0.01-41.73)	19.47 (0.01-42.52)	0.764
Chr2_RNASEH1	EUR	58.96 (37.72-73.87)	47.50 (26.38-78.10)	0.506
	NAT	26.92 (14.19-45.66)	31.59 (0.01-51.98)	0.885
	AFR	6.85 (0.01-28.24)	11.71 (0.01-27.86)	0.657
Chr2_IFIH1	EUR	41.90 (0.01-76.72)	42.42 (0.01-67.93)	0.708
	NAT	32.56 (0.01-55.56)	27.39 (2.01-56.89)	0.985
	AFR	14.99 (0.01-42.31)	0.01 (0.01-36.48)	0.654
Chr5_IL7R	EUR	13.27 (1.02-43.73)	9.19 (1.77-33.67)	0.555
	NAT	50.94 (38.08-98.60)	53.12 (31.82-95.13)	0.984
	AFR	14.68 (3.17-33.94)	17.98 (2.75-41.01)	0.634
Chr6_MHC	EUR	52.31 (37.26-72.43)	45.73 (19.25-67.03)	0.087
	NAT	20.32 (7.12-37.06)	31.88 (17.65-44.62)	0.019
	AFR	18.50 (3.21-36.04)	21.13 (0.53-36.56)	0.905
Chr10_NRP1	EUR	63.32 (28.61-69.09)	63.31 (6.89-63.32)	0.092
	NAT	36.67 (7.93-36.67)	36.67 (7.93-59.79)	0.282
	AFR	0.25 (1e-05-26.0)	0.52 (1e-05-37.80)	0.848

¹Mann-Whitney U test. AIMs: Ancestry informative markers; IQR: Interquartile range; Chr: Chromosome; EUR: European; NAT: Native American; AFR: African; T1AD: Autoimmune type 1 diabetes; T1BD: Idiopathic type 1 diabetes.