Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia

Table 1 Genetic ancestry of type 1 diabetes patients compared to Colombians living in Medellin control population

Chromosomal region	Ancestry	T1D, median (IQR)	CLM, median (IQR)	P value1
Overall AIMs	EUR	61.58 (52.84-69.85)	62.06 (49.67-73.74)	0.675
	NAT	27.34 (21.36-34.05)	25.46 (16.12- 32.90)	0.106
	AFR	10.28 (4.0-16.83)	10.65 (6.05-16.75)	0.575
Chr2_EFR3B	EUR	60.27 (34.05-80.79)	47.88 (34.04-76.43)	0.189
	NAT	24.30 (0.01-51.24)	37.10 (1.61-62.49)	0.02
	AFR	7.17 (0.01-25.05)	0.01 (0.01-15.67)	0.06
Chr2_CTLA4	EUR	46.24 (16.82-69.52)	58.26 (30.82-82.79)	0.167
	NAT	27.96 (0.04-41.31)	25.01 (0.01-45.16)	0.829
	AFR	20.54 (0.01-41.72)	11.78 (0.01-36.59)	0.183
Chr2_RNASEH1	EUR	56.91 (31.33-73.91)	58.80 (32.75-78.43)	0.482
	NAT	27.41 (11.69-46.36)	24.81 (0.01-48.84)	0.241
	AFR	8.37 (0.01-28.24)	13.04 (0.01-23.87)	0.430
Chr2_IFIH1	EUR	42.42 (0.01-77.63)	52.01 (16.33-82.16)	0.05
	NAT	32.07 (0.01-56.74)	14.99 (0.01-41.35)	0.246
	AFR	14.99 (0.01-32.31)	17.83 (0.01-42.31)	0.181
Chr5_IL7R	EUR	11.56 (1.04-41.14)	24.75 (7.20-46.98)	7.0 × 10-3
	NAT	52.18 (3.74-98.06)	39.18 (0.04-52.80)	1.0 × 10-4
	AFR	15.21 (3.0-35.75)	33.89 (11.23-59.94)	1.56 × 10-5
Chr6_MHC	EUR	51.35 (32.92-70.32)	55.86 (32.61-71.21)	0.76
	NAT	23.28 (8.92-40.0)	21.61 (5.83-43.13)	0.835
	AFR	18.87 (1.63-36.08)	19.53 (0.3-34.11)	0.660
Chr10_NRP1	EUR	63.32 (23.70-63.32)	0.03 (0.001-20.34)	2.2 × 10-16
	NAT	36.67 (7.93-36.67)	0.003 (0.001-7.93)	2.2 × 10-16
	AFR	0.03 (0.001-30.91)	94.23 (53.94-99.99)	2.2 × 10-16

¹Data from Mann-Whitney U test. AIMs: Ancestry informative markers; IQR: Interquartile range; CLM: Colombians living in Medellin from 1,000 genomes database; Chr: Chromosome; EUR: European; NAT: Native American; AFR: African; T1D: Type 1 diabetes.