Review
Copyright ©The Author(s) 2019.
World J Diabetes. Jan 15, 2019; 10(1): 1-15
Published online Jan 15, 2019. doi: 10.4239/wjd.v10.i1.1
Table 2 Biological, (patho)physiological and pharmacological factors influencing hemoglobin A1c
Factor influencing HbA1c synthesis/measurement/interpretation
Age, ethnicity
Genetic factors (e.g. Glucose-6-phosphate dehydrogenase variants)
Pregnancy
Red blood cell lifespan
Haemolytic anaemia
Iron deficiency anaemia
Haemoglobin variants
Accute haemorrhage
Splenomegaly
Splenectomy
Transfusion
Chronic liver disease
End-stage renal disease
Rheumatoid arthritis
Vitamin C
Drugs (aspirin, erytropoietin, dapsone, antiretroviral agents)
Endogenous interferents (high levels of bilirubin/triglycerides)