Update on biomarkers of glycemic control

doi:10.4239/wjd.v10.i1.1

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jan 15, 2019; 10(1): 1-15
Published online Jan 15, 2019. doi: 10.4239/wjd.v10.i1.1

Table 1 Characteristics of the analytical methods for hemoglobin A1c measurement

Method	Advantages	Disadvantages
Ion exchange chromatography	DCCT method, high reproducibility	Lack of specificity; interference from hemoglobinopathies and HbF
Capillary electrophoresis	High reproducibility; specificity	Time-consuming, costly
Boronate affinity chromatography	Minimal interference from hemoglobinopathies	Analyte-related unspecificity (total GHb)
Immunoassay	Specificity	Some interference from HbF

DCCT: Diabetes Control and Complications Trial; HbF: Fetal hemoglobin; GHb: Total glycated hemoglobin.

Citation: Krhač M, Lovrenčić MV. Update on biomarkers of glycemic control. World J Diabetes 2019; 10(1): 1-15
URL: https://www.wjgnet.com/1948-9358/full/v10/i1/1.htm
DOI: https://dx.doi.org/10.4239/wjd.v10.i1.1