Status of autoimmune diabetes 20-year after generation of BDC2.5-TCR transgenic non-obese diabetic mouse

Figure 1 Pathogenesis of type 1 diabetes includes four major steps: islet autoantigens are picked up by antigen presenting cells from the pancreas, which then migrate to draining lymph nodes and present the autoantigens to autoreactive T cells, leading to their priming. Activated autoreactive T cells undergo proliferation, differentiation, and acquire homing molecules that direct them to the pancreas where they infiltrate the islets resulting in insulitis and β cell destruction.